Cogoli M
Space Biology Group, Institute of Biotechnology, ETH-Hönggerberg, Zürich, Switzerland.
ASGSB Bull. 1992 Oct;5(2):59-67.
The fast rotating clinostat has been used in gravitational biology since 1965 to investigate effects of simulated microgravity. Using a microscope, the behavior of cells and organelles within the cells under microgravity conditions can be directly observed during rotation. Experiments with several mammalian cells and unicellular organisms have shown that different cellular functions are affected in simulated microgravity. Almost no changes were noted in the area of developmental biology. A comparison of results from the fast rotating clinostat and flight experiments reveals that the clinostat is a valuable tool to evaluate an organism's sensitivity to gravity changes. Therefore, a biological object proposed for a flight experiment should first be investigated in the clinostat before it is selected. This is especially true in the use of single cells and unicellular organisms.
自1965年以来，快速旋转的回转器一直用于重力生物学研究，以探究模拟微重力的影响。使用显微镜，可以在旋转过程中直接观察微重力条件下细胞及其内部细胞器的行为。对几种哺乳动物细胞和单细胞生物进行的实验表明，模拟微重力会影响不同的细胞功能。在发育生物学领域几乎未发现变化。快速旋转回转器实验结果与飞行实验结果的比较表明，回转器是评估生物体对重力变化敏感性的宝贵工具。因此，拟用于飞行实验的生物对象在被选中之前，应首先在回转器中进行研究。对于单细胞和单细胞生物的使用尤其如此。
