Suzuki Y, Kawakubo K, Makita Y, Goto S, Gunji A
Dept. of Health Administration, Faculty of Med., Univ. of Tokyo.
Physiologist. 1993 Feb;36(1 Suppl):S153-4.
It is well known that a daily positive physical activity is able to control body fat and to improve insulin action for intaking glucose in the muscles, especially under administration of nutrition in human. Conversely, when exposed prolonged inactive condition such as bed-rest in spite of control of nutrition, the insulin action may be declined due to less glucose intake in the muscles and thus the insulin secretion may be increased to maintain blood glucose level. If it is so, the increased insulin should accelerate intake of neutral fat and to lower fatty acid in the fat tissues. Further, if the prolonged inactivity would decrease plasma epinephrine and norepinephrine secretion, the breakdown of the stored fat should be declined due to declining hormone susceptible lipase secretion, resulting in increase in body fat, which may reflect the changes in lipo-proteins and apoproteins. In the present study, the hypothesis mentioned above were investigated in young persons exposed to prolonged horizontal bed-rest of 20 days.
众所周知，日常进行积极的体育活动能够控制体脂，并改善胰岛素在肌肉中摄取葡萄糖的作用，尤其是在人体摄入营养的情况下。相反，尽管营养得到控制，但当处于长时间不活动状态（如卧床休息）时，由于肌肉中葡萄糖摄入量减少，胰岛素作用可能会下降，从而胰岛素分泌可能会增加以维持血糖水平。如果是这样，增加的胰岛素会加速中性脂肪的摄取，并降低脂肪组织中的脂肪酸。此外，如果长时间不活动会减少血浆肾上腺素和去甲肾上腺素的分泌，由于激素敏感性脂肪酶分泌减少，储存脂肪的分解应该会下降，导致体脂增加，这可能反映了脂蛋白和载脂蛋白的变化。在本研究中，对暴露于20天长时间水平卧床休息的年轻人进行了上述假设的研究。
