Martel E, Champeroux P, Lacolley P, Cuche J L, Safar M E
CERB--chemin de Montifault, Baugy, France.
Physiologist. 1993 Feb;36(1 Suppl):S24-5.
In human zero gravity induces a cardiovascular deconditioning. The transfer of blood from the periphery to the thoracic compartment, occuring immediately at the beginning of the exposure to microgravity seems to be involved in this phenomenon. We have previously shown that LBNP (-40 mm Hg) produced an exaggerated heart rate response at the end of 24 hours of bed rest without modification of the cardiopulmonary receptors in human. Some other studies have shown that microgravity induces an impairment of the baroreflex sensitivity in human, but its involvement in the cardiovascular deconditioning is not completely understood. The aim of this study was to determine the modification of the arterial baroreflex using a model of simulated weightlessness in conscious rats during the exposure to microgravity.
在人类中，失重会导致心血管功能失调。在暴露于微重力环境开始时立即发生的血液从外周向胸腔腔室的转移似乎与这一现象有关。我们之前已经表明，在人类卧床休息24小时结束时，下体负压（-40 mmHg）会产生过度的心率反应，而心肺感受器并无改变。其他一些研究表明，微重力会导致人类压力反射敏感性受损，但其在心血管功能失调中的作用尚未完全了解。本研究的目的是在有意识的大鼠暴露于微重力环境期间，使用模拟失重模型来确定动脉压力反射的变化。
