Pedersen L, Arnfred T
Scand J Gastroenterol. 1975;10(5):557-60.
The pool size, half life, and daily production rate of chenodeoxycholic acid (CDCA) was determined by the isotope dilution method upon intravenous injections of about 10 muCI OF 24-14C-CDCA in 7 patients with radiolucent gallstones in functioning gallbladders, and 9 healthy controls. Bile was obtained by duodenal intubation. The method also allowed measurement of the CDCA percentage of total bile acids (TBA) and an indirect calculation of the TBA pool size. The pool size and daily production rate of CDCA were slightly, but not significantly, diminished in the gallstone patients. The half life of CDCA was almost equal in the 2 groups. The CDCA percentage of TBA was significantly higher in the gallstone patients (0.02 less than P less than 0.05), and the TBA pool size was significantly reduced (P less than 0.01) in the gallstone patients. It is concluded that the CDCA metabolism is similar to that of cholic acid in gallstone patients. Thus the formation of gallstones is hardly due to specific alterations in CDCA metabolism, suspected on account of the specific cholelitholytic effect of CDCA ingestion. The significance of increased CDCA percentage in bile is discussed in relation to the results from other study groups, and it is pointed out that a relative increase in the bile content of dihydroxy bile acids may lead to reduced cholesterol holding capacity of bile, and thus favor the formation of gallstones.
采用同位素稀释法，对7例胆囊功能正常但有透光性胆结石的患者及9名健康对照者静脉注射约10μCi的24-14C-鹅去氧胆酸（CDCA）后，测定了鹅去氧胆酸的池大小、半衰期和每日生成率。通过十二指肠插管获取胆汁。该方法还可测量鹅去氧胆酸占总胆汁酸（TBA）的百分比，并间接计算总胆汁酸池大小。胆结石患者的鹅去氧胆酸池大小和每日生成率略有降低，但无显著差异。两组中鹅去氧胆酸的半衰期几乎相等。胆结石患者中鹅去氧胆酸占总胆汁酸的百分比显著更高（0.02＜P＜0.05），且胆结石患者的总胆汁酸池大小显著减小（P＜0.01）。结论是，胆结石患者中鹅去氧胆酸的代谢与胆酸相似。因此，胆结石的形成几乎不是由于鹅去氧胆酸代谢的特定改变，尽管摄入鹅去氧胆酸有特定的溶石作用，但曾怀疑有这种改变。结合其他研究组的结果讨论了胆汁中鹅去氧胆酸百分比增加的意义，并指出二羟基胆汁酸胆汁含量的相对增加可能导致胆汁胆固醇容纳能力降低，从而有利于胆结石的形成。
