Musacchia X J
University of Louisville, KY, USA.
Physiologist. 1985;28(6 Suppl):S237-40.
The topics for this workshop were selected to illustrate the manner in which particular physiological and biochemical phenomena can be assessed using specific animal model systems. Our speakers presented data which offer comparisons of experiments in earthside laboratories with experiments using subjects which have experienced weightlessness in response to orbital flight. In addition, there have been speculative assertions that the earthside experiments mimic or simulate responses which one may expect to see with exposure to micro or zero gravity conditions. The topics focused on at least three areas that appear to be amenable to earthside investigations; in addition, they serve as primary areas for flight experimentation. As the result of animal and human exposures to microgravity experienced during orbital space flight, there is ample evidence of pathophysiological functional and structural alterations in muscle, bone, cardiovascular and related body fluid shift responses. This Animal Model Workshop represents the first of a series of sessions planned for further meetings of the IUPS Commission on Gravitational Physiology.
本次研讨会的主题旨在展示如何利用特定的动物模型系统评估特定的生理和生化现象。我们的演讲者展示的数据对地面实验室的实验与使用经历过轨道飞行失重的实验对象所做的实验进行了比较。此外，还有一些推测性的断言，即地面实验模拟了人们预期在微重力或零重力条件下会出现的反应。这些主题至少聚焦于三个似乎适合地面研究的领域；此外，它们也是飞行实验的主要领域。由于在轨道太空飞行中动物和人类经历了微重力，有充分证据表明肌肉、骨骼、心血管及相关体液转移反应存在病理生理功能和结构改变。本次动物模型研讨会是国际生理科学联合会重力生理学委员会后续会议计划系列会议中的第一场。
