Wu B, Xue Y, You G, Lu S, Xie B
Institute of Space Medico-Engineering, Beijing, China.
Space Med Med Eng (Beijing). 1997 Dec;10(6):439-42.
To find out a method to predict lower body negative pressure (LBNP) tolerance with noninvasive physiological measurements, 11 healthy young subjects were tested in an LBNP chamber in sitting position. Incremental negative pressure was used for evaluating LBNP tolerance time. End points of the test were onset of presyncopal symptoms or completion of 15 min test. According to their reactions, the 11 subjects were divided into good tolerance group (group A, n = 5) and poor tolerance group (group B, n = 6); At the 11th minute of LBNP, mean arterial pressure (MAP), magnitude of decrease of regional cerebral oxygen saturation (delta SrO2) and cardiac output (delta CO) showed significant difference between group A and B(P <0.05); Mean error was 0.54 +/- 0.42 min when LBNP tolerance was predicted using MAP and delta SrO2 at this moment by regression analysis.
为了找到一种通过无创生理测量来预测下体负压（LBNP）耐受性的方法，对11名健康的年轻受试者在LBNP舱中进行坐姿测试。采用递增负压来评估LBNP耐受时间。测试终点为晕厥前症状的出现或15分钟测试的完成。根据他们的反应，将11名受试者分为耐受性良好组（A组，n = 5）和耐受性差组（B组，n = 6）；在LBNP第11分钟时，A组和B组之间的平均动脉压（MAP）、局部脑氧饱和度下降幅度（delta SrO2）和心输出量（delta CO）存在显著差异（P <0.05）；此时通过回归分析使用MAP和delta SrO2预测LBNP耐受性时，平均误差为0.54±0.42分钟。
