3'-氨基-3'-脱氧鸟苷-5'-磷酰咪唑啉酸酯在d(CpCpCpCpC)模板上的寡聚化。

Oligomerization of 3'-amino-3'deoxyguanosine-5'phosphorimidazolidate on a d(CpCpCpCpC) template.

作者信息

Tohidi M, Zielinski W S, Chen C H, Orgel L E

机构信息

The Salk Institute for Biological Studies, San Diego, California 92138, USA.

出版信息

J Mol Evol. 1987;25:97-9. doi: 10.1007/BF02101750.

DOI:10.1007/BF02101750

PMID:11542079

Abstract

3'-Amino-3'-deoxyguanosine-5'-phosphorimidazolidate (ImpGNH2) oligomerizes more rapidly and regiospecifically than related nucleotide derivatives on a d(CpCpCpCpC) template. The greater nucleophilicity of the amino group leads to efficient oligomerization even when the structure of the double-helical complex formed by the template and the substrate is not optimal for reaction. The use of amine-containing analogues should permit us to develop models of potentially prebiotic polymerization reactions that cannot be studied easily using natural nucleotides.

摘要

3'-氨基-3'-脱氧鸟苷-5'-磷酰咪唑啉酸酯（ImpGNH2）在d（CpCpCpCpC）模板上比相关核苷酸衍生物更快且更具区域特异性地寡聚。即使模板和底物形成的双螺旋复合物结构并非最有利于反应，氨基更强的亲核性也能导致高效寡聚。使用含胺类似物应能让我们建立潜在的前生物聚合反应模型，而这些反应利用天然核苷酸难以轻易研究。