[心血管系统对下体负压反应的计算机模拟]
[Computer simulation of cardiovascular response to lower body negative pressure].
作者信息
Hao W Y, Wu X Y, Zhang L F, Feng L H, Sun X Q, Yao Y J
机构信息
Department of Aerospace Medicine, The Fourth Military Medical University, Xi'an, China.
出版信息
Space Med Med Eng (Beijing). 1999 Aug;12(4):262-6.
OBJECTIVE
To simulate the cardiovascular response to lower body negative pressure (LBNP).
METHOD
A computer model was developed. It had 7 subparts: the redistribution of blood, the filling of left ventricle, left ventricle, peripheral circulation, control of heart rate, control of peripheral resistance and control of venous tone. The heart rate and venous tone were controlled by high-pressure receptor baroreflex, while the peripheral resistance was controlled by high- and low-pressure receptor baroreflexes.
RESULT
With the help of the model, cardiovascular response to LBNP up to -10.64 kPa (-80 mmHg) were simulated, including the changes of systolic blood pressure, mean blood pressure, heart rate and cardiac output. The time-dependent response to a LBNP profile was also simulated. The simulation results coincided well with human experiments.
CONCLUSION
The model is valid and can accurately reproduce the short-term hemodynamic response to LBNP.
目的
模拟下半身负压（LBNP）时的心血管反应。
方法
开发了一个计算机模型。它有7个部分：血液重新分布、左心室充盈、左心室、外周循环、心率控制、外周阻力控制和静脉张力控制。心率和静脉张力由高压感受器压力反射控制，而外周阻力由高压和低压感受器压力反射控制。
结果
借助该模型，模拟了高达-10.64 kPa（-80 mmHg）的LBNP时的心血管反应，包括收缩压、平均血压、心率和心输出量的变化。还模拟了对LBNP曲线的时间依赖性反应。模拟结果与人体实验结果吻合良好。
结论
该模型有效，能够准确再现对LBNP的短期血流动力学反应。
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