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[Ligands of opioid and sigma receptors and correction of cardiac electrical instability in post-infarction cardiosclerosis].

作者信息

Maslov L N, Lishmanov Iu B, Naryzhnaia N V, Krylatov A V, Tam S V

机构信息

Laboratory of Experimental Cardiology, Institute of Cardiology, Tomsk Scientific Center, Siberian Division, Russian Academy of Medical Sciences, ul. Kievskaya 111, Tomsk, 634050 Russia.

出版信息

Eksp Klin Farmakol. 2001 Jan-Feb;64(1):38-41.

PMID:11544802
Abstract

Peripheral administration of the mu- or kappa-receptor agonists or sigma-receptor antagonists produced a significant receptor-dependent increase in the ventricular fibrillation threshold in rats with postinfarction cardiosclerosis. The effect was not observed upon administration of the epsilon-receptor agonist beta-endorphin. The receptor and molecular mechanisms of the observed effects are discussed.

摘要

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