Vengerovskiĭ A I, Golovina E L, Burkova V N, Saratikov A S
Pharmacology Department, Siberian Medical University, Moskovskii Trakt 2, Tomsk, 634050 Russia.
Eksp Klin Farmakol. 2001 Jan-Feb;64(1):46-8.
The administration of eplir (a phospholipid-containing hepatoprotector), as well as of the enterosorbents polyphepan and EST-1 (an agent obtained from dry peat extract), to rats with tetrachloromethane-induced hepatitis protect the liver parenchyma against dystrophy, necrosis, and inflammation, reduce hyperfermentemia, decrease the blood bilirubin, ammonia, phenols, and malonaldehyde, and increase the urea content in blood serum, while not fully restoring all these biochemical parameters on the normal level. The treatment of rats with toxic hepatitis by a combination of eplir and enterosorbents is accompanied by a synergistic increase in the therapeutic efficacy of each component, leading to normalization of the biochemical parameters reflecting the functional slate of liver.
给四氯化碳诱导肝炎的大鼠施用埃普利尔（一种含磷脂的肝保护剂）以及肠吸附剂聚多酚和EST - 1（一种从干泥炭提取物中获得的制剂），可保护肝实质免受营养不良、坏死和炎症影响，降低高酶血症，减少血胆红素、氨、酚和丙二醛含量，并增加血清尿素含量，不过并未使所有这些生化参数完全恢复至正常水平。用埃普利尔和肠吸附剂联合治疗大鼠中毒性肝炎时，各组分的治疗效果会协同增强，导致反映肝脏功能状态的生化参数恢复正常。
