吡啶-3-乙醛酸的降血脂及抗氧化作用
[Hypolipidemic and antioxidant effects of pyridyl-3-glyoxylic acid].
作者信息
Sadykova Kh U, Abdullaev A Kh
机构信息
Department of Propedeutics of Internal Disorders, First State Medical Institute, ul. Khamzy 103, Tashkent, 700047 Uzbekistan.
出版信息
Eksp Klin Farmakol. 2001 Jan-Feb;64(1):57-9.
PMID:11544807
Abstract
Pyridyl-3-glyoxylic acid reduced the blood cholesterol and triglycerides, normalized the lipoprotein spectrum, markedly decreased the intensity of lipid peroxidation, and increased the superoxide dismutase enzyme activity in the experimental rabbits with cholesterol atherosclerosis model. The efficacy of the compound exceeded that of nicotinic acid used as the reference compound.
摘要
吡啶-3-乙醛酸降低了实验性胆固醇动脉粥样硬化模型兔的血液胆固醇和甘油三酯水平，使脂蛋白谱正常化，显著降低了脂质过氧化强度，并提高了超氧化物歧化酶的酶活性。该化合物的疗效超过了用作参比化合物的烟酸。
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