What roles do growth factors play in CNS remyelination?
作者信息
Franklin R J, Hinks G L, Woodruff R H, O'Leary M T
机构信息
Department of Clinical Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge CB3 0ES, UK.
出版信息
Prog Brain Res. 2001;132:185-93. doi: 10.1016/S0079-6123(01)32075-7.
Abstract
摘要
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The oligodendrocyte and its many cellular processes.少突胶质细胞及其众多细胞突起。
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The demonstration by transplantation of the very restricted remyelinating potential of post-mitotic oligodendrocytes.通过移植有丝分裂后少突胶质细胞非常有限的髓鞘再生潜能所进行的证明。
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Delayed changes in growth factor gene expression during slow remyelination in the CNS of aged rats.老年大鼠中枢神经系统缓慢髓鞘再生过程中生长因子基因表达的延迟变化。
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Transplantation options for therapeutic central nervous system remyelination.用于治疗性中枢神经系统髓鞘再生的移植选择。
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Temporal analysis of growth factor mRNA expression in myelinating rat brain aggregate cultures: increments in CNTF, FGF-2, IGF-I, and PDGF-AA mRNA are induced by antibody-mediated demyelination.大鼠脑髓鞘形成聚集培养物中生长因子mRNA表达的时间分析：抗体介导的脱髓鞘诱导睫状神经营养因子（CNTF）、碱性成纤维细胞生长因子（FGF-2）、胰岛素样生长因子-I（IGF-I）和血小板衍生生长因子-AA（PDGF-AA）mRNA增加。
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Generation of oligodendroglial progenitors in acute inflammatory demyelinating lesions of the rat brain stem is associated with demyelination rather than inflammation.大鼠脑干急性炎性脱髓鞘病变中少突胶质前体细胞的生成与脱髓鞘有关，而非炎症。
J Neurocytol. 1999 Apr-May;28(4-5):365-81. doi: 10.1023/a:1007069815302.
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Activation and proliferation of endogenous oligodendrocyte precursor cells during ethidium bromide-induced demyelination.溴化乙锭诱导脱髓鞘过程中内源性少突胶质细胞前体细胞的激活与增殖
Exp Neurol. 1999 Dec;160(2):333-47. doi: 10.1006/exnr.1999.7224.
9
Progenitor cells of the adult mouse subventricular zone proliferate, migrate and differentiate into oligodendrocytes after demyelination.成年小鼠脑室下区的祖细胞在脱髓鞘后会增殖、迁移并分化为少突胶质细胞。
Eur J Neurosci. 1999 Dec;11(12):4357-66. doi: 10.1046/j.1460-9568.1999.00873.x.
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Identification, isolation, and promoter-defined separation of mitotic oligodendrocyte progenitor cells from the adult human subcortical white matter.从成年人类皮质下白质中鉴定、分离有丝分裂少突胶质细胞祖细胞并进行启动子定义的分离。
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