Brück Wolfgang, Kuhlmann Tanja, Stadelmann Christine
Institut für Neuropathologie, Charité, Campus Virchow-Klinikum, Humboldt-Universität, Augustenburger Platz 1, 13353, Berlin, Germany.
J Neurol Sci. 2003 Feb 15;206(2):181-5. doi: 10.1016/s0022-510x(02)00191-0.
Remyelination in multiple sclerosis (MS) lesions has been described in several studies. It depends on the presence of myelinating oligodendrocytes and a functional interaction between these myelinating cells and axons. The imaging signal of remyelination in magnetic resonance imaging or spectroscopy is not yet defined. The present review will focus on the morphological appearance of remyelinating MS lesions, their correlation with oligodendrocyte pathology, and possible markers for remyelination in imaging.
多项研究已对多发性硬化症（MS）病灶中的再髓鞘化进行了描述。它取决于有髓鞘形成的少突胶质细胞的存在以及这些有髓鞘形成的细胞与轴突之间的功能相互作用。磁共振成像或波谱学中再髓鞘化的成像信号尚未明确。本综述将聚焦于MS再髓鞘化病灶的形态学表现、它们与少突胶质细胞病理学的相关性以及成像中再髓鞘化的可能标志物。
