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一项脑磁图研究中的短暂性全面性遗忘症(TGA)

Transient global amnesia (TGA) in an MEG study.

作者信息

Mizuno-Matsumoto Y, Ishijima M, Shinosaki K, Nishikawa T, Ukai S, Ikejiri Y, Nakagawa Y, Ishii R, Tokunaga H, Tamura S, Date S, Inouy T, Shimojo S, Takeda M

机构信息

Department of Human Welfare, Osaka Jonan Women's College, Japan.

出版信息

Brain Topogr. 2001 Summer;13(4):269-74. doi: 10.1023/a:1011176612377.

Abstract

A patient who had experienced an attack of transient global amnesia (TGA) was examined using neurophysiological methods. Magnetoencephalography (MEG) was performed and the Wechsler Memory Scale-Revised (WMS-R) test was administered at 5 days and at more than a month after the TGA episode. MEG data on neuronal activity obtained while the patient was undertaking a working memory task and during rest were analyzed using the wavelet-crosscorrelation method, which reveals time-lag and information flow between related sites in the brain. The WMS-R memory scores showed dramatic improvement when the test was administered a month following the attack, although no significant changes were observed in EEG, MRI and SPECT data. The MEG study revealed that under a working memory load how the neuron works functionally and the information propagates assembly within the right hemisphere, and that these brain functions were not performed adequately shortly after the TGA attack.

摘要

一名经历过短暂性全面性遗忘症(TGA)发作的患者接受了神经生理学方法检查。在TGA发作后的第5天以及一个多月后进行了脑磁图(MEG)检查,并实施了韦氏记忆量表修订版(WMS-R)测试。使用小波互相关方法分析了患者在进行工作记忆任务和休息期间获得的关于神经元活动的MEG数据,该方法揭示了大脑中相关部位之间的时间滞后和信息流。尽管脑电图(EEG)、磁共振成像(MRI)和单光子发射计算机断层扫描(SPECT)数据未观察到显著变化,但在发作一个月后进行测试时,WMS-R记忆分数显示出显著改善。MEG研究表明,在工作记忆负荷下,神经元如何在功能上发挥作用以及信息如何在右半球内传播组合,并且这些脑功能在TGA发作后不久并未充分发挥。

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