Takahashi N, Fujibayashi Y, Yonekura Y, Welch M J, Waki A, Tsuchida T, Sadato N, Sugimoto K, Nakano A, Lee J D, Itoh H
Department of Radiology, Fukui Medical University, Japan.
Ann Nucl Med. 2001 Jun;15(3):293-6. doi: 10.1007/BF02987849.
Copper-62 labeled diacetyl-bis(N4-methylthiosemicarbazone) (62Cu-ATSM) has been proposed as a generator produced positron-emitting tracer for hypoxic tissue imaging. To clarify the usefulness of 62Cu-ATSM for myocardial ischemia, 62Cu-ATSM PET was performed in 7 patients with coronary artery disease. Increased myocardial uptake of 62Cu-ATSM was observed (myocardium/blood ratio: 3.09) in one patient with unstable angina, who had increased 18F-fluorodeoxyglucose (18F-FDG) uptake under the fasting condition. The other 6 patients, who were clinically stable, did not have increased 62Cu-ATSM uptake, although abnormal 18F-FDG uptake was seen in 4 patients. This preliminary study suggests that 62Cu-ATSM is a promising PET tracer for hypoxic imaging in acute ischemia.
铜-62标记的双乙酰双（N4-甲基硫代半卡巴腙）（62Cu-ATSM）已被提议作为一种由发生器产生的用于缺氧组织成像的正电子发射示踪剂。为阐明62Cu-ATSM对心肌缺血的实用性，对7例冠状动脉疾病患者进行了62Cu-ATSM正电子发射断层显像（PET）。在1例不稳定型心绞痛患者中观察到62Cu-ATSM心肌摄取增加（心肌/血液比值：3.09），该患者在禁食状态下18F-氟脱氧葡萄糖（18F-FDG）摄取增加。其他6例临床稳定的患者，尽管其中4例患者18F-FDG摄取异常，但62Cu-ATSM摄取并未增加。这项初步研究表明，62Cu-ATSM是一种用于急性缺血缺氧成像的有前景的PET示踪剂。
