Hepp R, Langley K
INSERM Unité 338, Biologie de la Communication Cellulaire, Strasbourg, France.
Cell Tissue Res. 2001 Aug;305(2):247-53. doi: 10.1007/s004410100359.
Soluble N-ethylmaleimide-sensitive factor attached protein receptor (SNARE) molecules are implicated in many fundamental cellular processes that require membrane fusion, and the interactions of the SNARE proteins, SNAP-25, syntaxin and VAMP/synaptobrevin, have been extensively studied. This review documents recent data on their role at different stages of development. SNARE proteins are expressed very early and play important roles in fertilization and in cell division during early embryogenesis. In the developing nervous system, they are important for neurite outgrowth and transformation of the growth cone into the mature synapse. In the neuroendocrine system, in addition to neurosecretion, they are involved in processes related to morphological plasticity. Although few data exist on regulation of SNARE proteins during development, growth factors, intracellular messengers and depolarization are known to modify their cellular expression. The putative importance of these factors during development is discussed.
可溶性N - 乙基马来酰亚胺敏感因子附着蛋白受体（SNARE）分子参与许多需要膜融合的基本细胞过程，并且SNARE蛋白、SNAP - 25、 syntaxin和VAMP / 突触囊泡蛋白的相互作用已得到广泛研究。本综述记录了关于它们在发育不同阶段作用的最新数据。SNARE蛋白在很早的时候就开始表达，并在受精和早期胚胎发育期间的细胞分裂中发挥重要作用。在发育中的神经系统中，它们对于神经突生长以及生长锥向成熟突触的转变很重要。在神经内分泌系统中，除了神经分泌外，它们还参与与形态可塑性相关的过程。尽管关于发育过程中SNARE蛋白的调节的数据很少，但已知生长因子、细胞内信使和去极化会改变它们在细胞中的表达。本文讨论了这些因子在发育过程中的假定重要性。
