确定2型糖尿病的遗传因素。
Defining the genetic contribution of type 2 diabetes mellitus.
作者信息
van Tilburg J, van Haeften T W, Pearson P, Wijmenga C
机构信息
Department of Medical Genetics, KC.04.084.2, University Medical Centre Utrecht, 3508 AB Utrecht, The Netherlands.
出版信息
J Med Genet. 2001 Sep;38(9):569-78. doi: 10.1136/jmg.38.9.569.
Abstract
Type 2 diabetes mellitus is a common multifactorial genetic syndrome, which is determined by several different genes and environmental factors. It now affects 150 million people world wide but its incidence is increasing rapidly because of secondary factors, such as obesity, hypertension, and lack of physical activity. Many studies have been carried out to determine the genetic factors involved in type 2 diabetes mellitus. In this review we look at the different strategies used and discuss the genome wide scans performed so far in more detail. New technologies, such as microarrays, and the discovery of SNPs will lead to a greater understanding of the pathogenesis of type 2 diabetes mellitus and to better diagnostics, treatment, and eventually prevention.
摘要
2型糖尿病是一种常见的多因素遗传综合征，由多种不同基因和环境因素决定。目前全球有1.5亿人受其影响，但其发病率因肥胖、高血压和缺乏体育活动等次要因素而迅速上升。已经开展了许多研究来确定与2型糖尿病相关的遗传因素。在这篇综述中，我们将探讨所采用的不同策略，并更详细地讨论迄今为止进行的全基因组扫描。微阵列等新技术以及单核苷酸多态性的发现将使人们对2型糖尿病的发病机制有更深入的了解，并有助于更好地进行诊断、治疗以及最终的预防。
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