Shibata A, Stamey T A, McNeal J E, Cheng I, Peehl D M
Department of Health Research and Policy, Stanford University School of Medicine, Stanford, California, USA.
J Urol. 2001 Oct;166(4):1560-4.
We examined the association of androgen receptor gene cytosine-adenine-guanine (CAG) repeat length and the 2 single nucleotide polymorphisms A49T and V89L in the type II 5 alpha-reductase gene with prostate enlargement measured as the weight of the surgically removed prostate.
A total of 68 men with a prostate weighing 80 gm. or greater were compared with 197 controls with a prostate weighing less than 80 gm. These men had undergone radical prostatectomy between 1992 and 1996. DNA was extracted from archival prostate tissue uninvolved with cancer and genotyped for 3 polymorphic markers. The effects of genetic variants and clinicopathological variables on prostate enlargement risk were estimated by logistic regression.
The age adjusted odds ratio estimate of prostate enlargement risk in men with 23 or greater versus 20 or fewer CAG repeats was 0.41 (95% confidence interval 0.19 to 0.89). This risk reduction was consistently found when an alternative prostate enlargement definition and subject restriction were used. No consistent association with prostate enlargement risk was observed for A49T or V89L polymorphisms.
Our finding further supports the hypothesis that the shorter CAG repeat length of the androgen receptor gene is related to prostate enlargement.
我们研究了雄激素受体基因胞嘧啶 - 腺嘌呤 - 鸟嘌呤（CAG）重复长度以及II型5α - 还原酶基因中的两个单核苷酸多态性A49T和V89L与以手术切除前列腺重量衡量的前列腺增生之间的关联。
总共68名前列腺重量为80克或更重的男性与197名前列腺重量小于80克的对照者进行比较。这些男性在1992年至1996年间接受了根治性前列腺切除术。从无癌的存档前列腺组织中提取DNA，并对3个多态性标记进行基因分型。通过逻辑回归估计基因变异和临床病理变量对前列腺增生风险的影响。
CAG重复次数为23次或更多与20次或更少的男性相比，年龄调整后的前列腺增生风险比值比估计值为0.41（95%置信区间0.19至0.89）。当使用替代的前列腺增生定义和受试者限制时，始终发现这种风险降低。未观察到A49T或V89L多态性与前列腺增生风险有一致的关联。
我们的发现进一步支持了雄激素受体基因CAG重复长度较短与前列腺增生相关的假说。
