Brousse C, Nguyen-Plantin S, Friard S, Grenet D, Stern M
Groupe de transplantation pulmonaire, Hôpital Foch, BP 36, 40 rue Worth, 92150 Suresnes, France.
Rev Mal Respir. 2001 Sep;18(4 Pt 1):411-5.
We evaluated bone mineral density and phosphorus calcium status in patients with chronic lung diseases.
A prospective study was conducted in 58 patients (43 men and 15 women, mean age 44 years, age range 16-68 years) who were classed in three groups: chronic obstructive diseases (25 patients), cystic fibrosis (19 patients), and other lung diseases (14 patients). Fifteen percent of the patients were receiving corticosteroid therapy. Bone mineral density of the lumbar spin and the femoral neck was measured.
Serum calcium, phosphate, creatinine, osteocalcin and parathyroid hormone were normal. The 25-hydroxyvitamin D (normal=9-40 ng/ml) level was in the lower limits of normal (12 ng/ml) and was severely decreased in 12 patients (<7 ng/ml).
Chronic lung disease can lead to osteoporosis. Corticosteroids, low vitamin D level, sedentary lifestyle, smoking, and in cystic fibrosis nutritional deficiencies, delayed puberty and hypogonadism are risk factors. Bone density must be measured in order to prevent and treat osteoporosis.
我们评估了慢性肺部疾病患者的骨矿物质密度和磷钙状况。
对58例患者（43名男性和15名女性，平均年龄44岁，年龄范围16 - 68岁）进行了一项前瞻性研究，这些患者被分为三组：慢性阻塞性疾病（25例）、囊性纤维化（19例）和其他肺部疾病（14例）。15%的患者正在接受皮质类固醇治疗。测量了腰椎和股骨颈的骨矿物质密度。
血清钙、磷、肌酐、骨钙素和甲状旁腺激素均正常。25 - 羟基维生素D（正常范围 = 9 - 40 ng/ml）水平处于正常下限（12 ng/ml），12例患者（<7 ng/ml）严重降低。
慢性肺部疾病可导致骨质疏松。皮质类固醇、低维生素D水平、久坐的生活方式、吸烟，以及囊性纤维化患者的营养缺乏、青春期延迟和性腺功能减退都是危险因素。必须测量骨密度以预防和治疗骨质疏松症。
