Silverberg D, Mayo A, Paran H, Silverberg R, Freund U
Department of Surgery A, Meir Hospital, Kfar-Saba, Israel.
Harefuah. 2001 Aug;140(8):682-5, 808.
Colonic Pseudo-obstruction is a poorly understood syndrome. It was first described by Ogilvie in 1948 and is characterized by signs of large bowel obstruction with a non-mechanical etiology. The suggested cause of this pathophysiology is an imbalance in the autonomic nerve supply to the colon. The syndrome affects mainly old, bedridden patients, usually hospitalised for non-colonic causes. The actual incidence of this syndrome is unknown, mainly due to the fact that spontaneous recovery may occur. When massive abdominal distention is apparent, diagnosis and treatment are usually problematic and other causes of obstruction must be ruled out. It is usually managed by water soluble contrast administered orally or rectally, or by colonic decompression. In extreme cases surgical treatment is required with significant morbidity and mortality. Pharmacologic management with parasympathomimetic drugs has been suggested recently. We describe the successful treatment of a patient with neostigmine and review the current literature.
结肠假性梗阻是一种了解甚少的综合征。它于1948年由奥吉尔维首次描述，其特征为具有非机械性病因的大肠梗阻迹象。这种病理生理学的推测病因是结肠自主神经供应失衡。该综合征主要影响老年卧床患者，这些患者通常因非结肠原因住院。该综合征的实际发病率未知，主要是因为可能会自发恢复。当出现明显的腹部膨隆时，诊断和治疗通常存在问题，必须排除其他梗阻原因。通常通过口服或直肠给予水溶性造影剂，或通过结肠减压来处理。在极端情况下，需要进行手术治疗，且有显著的发病率和死亡率。最近有人提出用拟副交感神经药物进行药物治疗。我们描述了用新斯的明成功治疗一名患者的情况并综述了当前的文献。
