Krone L R, Prichard L L, Bradshaw C L, Jones O W, Peterson R M, Dixson B K
West J Med. 1975 Jul;123(1):17-21.
This report describes the first antenatal diagnosis of an XXX female. Over 150 postnatal cases of XXX females have been described. There is no specific phenotype associated with the sex chromosome abnormality and most such persons are fertile. The frequency of XXX females in mental institutions is 3.9 per 1,000 female subjects whereas the frequency in consecutive newborn infants is 1.1 per 1,000 newborns. Chi-square analysis shows this difference cannot be due to chance. On the other hand, data from consecutive newborn studies suggest that intellectual development in XXX newborns is within normal range. Available evidence favors normal development in XXX female infants although the risk for developmental disabilities may be higher for the XXX than for the XX infant.
本报告描述了首例产前诊断出的XXX女性。已报道了150多例产后XXX女性病例。与性染色体异常相关的并无特定表型，且大多数此类个体具有生育能力。在精神病院中，XXX女性的出现频率为每1000名女性受试者中有3.9例，而在连续出生的新生儿中，这一频率为每1000名新生儿中有1.1例。卡方分析表明，这种差异并非偶然。另一方面，连续新生儿研究的数据表明，XXX新生儿的智力发育在正常范围内。现有证据支持XXX女婴正常发育，尽管XXX婴儿比XX婴儿出现发育障碍的风险可能更高。
