[乳酸菌在霍乱预防和治疗中功效的实验评估]

[Experimental evaluation of efficacy of Lactobacilli in prophylaxis and treatment of cholera].

作者信息

Bardykh I D, Krylikov V D, Mazrukho B L, Ryzhko I V, Moskvitina E A, Tsuraeva R I, Vinokur N I, Drobotkovskaia N V

机构信息

Research Institute for Plague Control, Rostov-on-Don, Russia.

出版信息

Zh Mikrobiol Epidemiol Immunobiol. 2001 Mar-Apr(2):68-71.

PMID:11548265

Abstract

Investigations on experimental models of cholera ("sealed" mice and suckling rabbits) demonstrated that previous daily oral administration of the ferment culture of Lactobacillus acidophilus BKM B-2020[symbol: see text] in a dose of 3.0 x 10(8) microbial cells/ml daily for 5-7 days prevented to the development of Vibrio cholerae infection. The curative effect observed after 3 administrations of lactobacilli within 48 hours after infection with V. cholerae was registered in 50% of cases. This strain of lactobacilli was found to be suitable for use as the basis component of probiotic, an additional remedy for the prophylaxis and treatment of cholera.

摘要

对霍乱实验模型（“封闭”小鼠和乳兔）的研究表明，先前每日口服嗜酸乳杆菌BKM B - 2020[符号：见原文]的发酵培养物，剂量为3.0×10⁸个微生物细胞/毫升，持续5 - 7天，可预防霍乱弧菌感染的发生。在感染霍乱弧菌后48小时内给予3次乳酸杆菌后，50%的病例观察到了治疗效果。发现这种乳酸杆菌菌株适合用作益生菌的基础成分，作为预防和治疗霍乱的辅助药物。