Khnychenko L K, Bul'on V V, Sapronov N S
Department of Neuropharmacology, Institute of Experimental Medicine, Russian Academy of Medical Sciences, ul. Akademika Pavlova 12, St. Petersburg, 197376 Russia.
Eksp Klin Farmakol. 2001 Mar-Apr;64(2):38-40.
The effects of TAU-5, a new N-phenylalkyl derivative of taurine, on the metabolic changes in heart were studied in rats with experimental myocardial infarction. The new drug exhibits a pronounced antiischemic effect related to recovery of the activity of enzymes involved in the energy exchange, decrease in the rate of lipid peroxidation, and normalization of the function of enzymes responsible for the antioxidant activity. The results of the pathomorphologic analysis and data on the state of cardiac metabolism showed that the antiischemic effect of TAU-5 is comparable with that of neoton.
在实验性心肌梗死大鼠中研究了牛磺酸的一种新型N-苯基烷基衍生物TAU-5对心脏代谢变化的影响。这种新药表现出明显的抗缺血作用，这与参与能量交换的酶活性恢复、脂质过氧化速率降低以及负责抗氧化活性的酶功能正常化有关。病理形态学分析结果和心脏代谢状态数据表明，TAU-5的抗缺血作用与neoton相当。
