Nikitin V P, Kozyrev S A, Shevelkin A V
Anokhin Institute of Normal Physiology, Russian Academy of Medical Sciences, Moscow.
Zh Vyssh Nerv Deiat Im I P Pavlova. 2001 Mar-Apr;51(2):206-12.
The effects of N-methyl-D-aspartate (NMDA) glutamate receptor antagonist (+)-MK-801 hydrogen maleate (MR801) on plasticity of different sensory inputs of the L-RPl1 command neurons were studied in Helix lucorum snail during nociceptive sensitization. Application of sensitizing stimulation onto the snail head or foot in the control semi-intact preparation initiated depression of neural responses evoked by tactile or chemical sensory stimulation during the short-term period of sensitization and significant facilitation of neural responses during the long-period of sensitization. Sensitizing stimulation of snail head against the background of MK-801 application (10-30 microM) produced a pronounced depression of neural responses to chemical stimulation of the head both in the short- and long-term sensitization periods. At the same time, sensitizing stimulation of the foot or head during the MK-801 application produced the same changes in neural responses to chemical stimulation of the foot and tactile stimulation of the foot or head as in the control preparation. It can be suggested that NMDA-like glutamate receptors are selectively involved in the mechanisms of plasticity induction in the synaptic inputs of the command LPl1 and RPl1 neurons, which process the information resulting from chemical excitation of the snail head (a specific receptor skin site for these neurons in Helix lucorum).
在伤害性致敏过程中，研究了N-甲基-D-天冬氨酸（NMDA）谷氨酸受体拮抗剂马来酸氢（+）-MK-801（MR801）对光亮大蜗牛中L-RPl1指令神经元不同感觉输入可塑性的影响。在对照半完整制剂中，对蜗牛头部或足部施加致敏刺激，在致敏短期引发触觉或化学感觉刺激诱发的神经反应抑制，在致敏长期则引发神经反应显著增强。在应用MK-801（10-30 microM）的背景下，对蜗牛头部进行致敏刺激，在短期和长期致敏期均对头部化学刺激的神经反应产生明显抑制。同时，在应用MK-801期间，对足部或头部进行致敏刺激，对足部化学刺激以及足部或头部触觉刺激的神经反应产生的变化与对照制剂相同。可以认为，NMDA样谷氨酸受体选择性参与指令LPl1和RPl1神经元突触输入可塑性诱导机制，这些神经元处理来自蜗牛头部化学刺激产生的信息（在光亮大蜗牛中，这些神经元的特定受体皮肤部位）。
