干扰素-γ在冠状动脉旁路移植术中的意义。
Significance of interferon-gamma in coronary artery bypass surgery.
作者信息
Alrawi S J, Abo Deeb A A, Samee M, Raju R, Shirazian D, Acinapura A J, Cunningham J N
机构信息
Department of Surgery, Research Institute of MMC & LMC, Maimonides Medical Center, Brooklyn, New York 11219, USA.
出版信息
JSLS. 2001 Jul-Sep;5(3):249-53.
BACKGROUND
Gamma interferon (IFN-gamma) is produced by activated natural killer and T cells under pathologic circumstances. The objective of our study was to compare the level of IFN-gamma in open and endoscopic methods of vein harvesting for coronary artery bypass surgery (CABG).
METHOD
Ninety samples of human saphenous veins harvested from patients prepared for CABG. Pre- and post-procedure sera of the patients, in addition to supernatants of 3-day endothelial cell culture, were analyzed for IFN-gamma.
RESULTS
The mean preoperative IFN-gamma level (0.09+/-0.03 pg/mL) and that for postoperative sera (0.08+/-0.02 pg/mL) were not significantly different (P = 0.2). The mean IFN-gamma level in endothelial cell culture from the endoscopic (0.18+/-0.21 pg/mL) and the open method (0.19+/-0.39 pg/mL) were not significant (P = 0.89).
CONCLUSION
We recommend the endoscopic method of vein harvesting because of its lower morbidity and earlier hospital discharge.
背景
γ干扰素（IFN-γ）在病理情况下由活化的自然杀伤细胞和T细胞产生。我们研究的目的是比较冠状动脉旁路移植术（CABG）中开放和内镜下静脉采集方法中IFN-γ的水平。
方法
从准备进行CABG的患者身上采集90份人隐静脉样本。除了对患者术前和术后的血清进行分析外，还对3天内皮细胞培养的上清液进行IFN-γ分析。
结果
术前IFN-γ平均水平（0.09±0.03 pg/mL）与术后血清水平（0.08±0.02 pg/mL）无显著差异（P = 0.2）。内镜下（0.18±0.21 pg/mL）和开放方法（0.19±0.39 pg/mL）的内皮细胞培养中IFN-γ平均水平无显著差异（P = 0.89）。
结论
由于内镜下静脉采集方法发病率较低且出院较早，我们推荐使用该方法。
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