带有碱性侧链的呋喃类化合物：一系列对雌激素受体α具有选择性的新型拮抗剂的合成与生物学评价
Furans with basic side chains: synthesis and biological evaluation of a novel series of antagonists with selectivity for the estrogen receptor alpha.
作者信息
Mortensen D S, Rodriguez A L, Sun J, Katzenellenbogen B S, Katzenellenbogen J A
机构信息
Department of Chemistry, University of Illinois, Urbana, 61801, USA.
出版信息
Bioorg Med Chem Lett. 2001 Sep 17;11(18):2521-4. doi: 10.1016/s0960-894x(01)00488-7.
Abstract
3-alkyl-2,4,5-triarylfurans with basic side-chain substituents were prepared as ligands for the estrogen receptor. Those analogues having the basic side chain on the C(4) phenol were high-affinity, ERalpha-selective antagonists.
摘要
制备了带有碱性侧链取代基的3-烷基-2,4,5-三芳基呋喃作为雌激素受体的配体。那些在C(4)位酚上带有碱性侧链的类似物是高亲和力、ERα选择性拮抗剂。
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