Vesely D L, San Miguel G I, Hassan I, Schocken D D
Division of Cardiology, Department of Internal Medicine, University of South Florida Health Sciences Center, Tampa, Florida 33612, USA.
J Clin Endocrinol Metab. 2001 Sep;86(9):4244-9. doi: 10.1210/jcem.86.9.7829.
The present investigation was designed to determine whether atrial natriuretic peptides consisting of amino acids 1-30 (i.e. long-acting natriuretic hormone), 31-67 (vessel dilator), 79-98 (kaliuretic hormone), and 99-126 (atrial natriuretic hormone) of the 126 amino acid atrial natriuretic hormone prohormone decrease CRH, ACTH, and/or cortisol in healthy humans (n = 30). Vessel dilator, kaliuretic hormone, long-acting natriuretic hormone, and atrial natriuretic hormone decreased the circulating concentration of CRH 84%, 74%, 67%, and 62% (P < 0.001 for each), respectively, when infused at 100 ng/kg body weight.min for 60 min. Vessel dilator, kaliuretic hormone, long-acting natriuretic hormone, and atrial natriuretic hormone decreased circulating ACTH concentrations 58%, 80%, 81%, and 70% (P < 0.001) and the circulating concentration of cortisol 73%, 72%, 73%, and 67% (P < 0.001), respectively. The decreases in CRH, ACTH, and cortisol lasted 11/2 to 3 h after cessation of the respective atrial natriuretic peptide infusions. These data, along with the knowledge that cortisol upregulates atrial natriuretic peptides' gene expression and CRH and ACTH stimulate atrial natriuretic peptides' release, suggest that these four atrial natriuretic peptides may be part of an intricate feedback system to help regulate cortisol concentrations via their ability to decrease the circulating concentration of CRH which, in turn, results in a decrease in ACTH and cortisol.
本研究旨在确定由126个氨基酸的心房利钠激素原激素的1-30位氨基酸（即长效利钠激素）、31-67位氨基酸（血管扩张剂）、79-98位氨基酸（促尿钾排泄激素）和99-126位氨基酸（心房利钠激素）组成的心房利钠肽是否会降低健康人（n = 30）体内的促肾上腺皮质激素释放激素（CRH）、促肾上腺皮质激素（ACTH）和/或皮质醇水平。当以100 ng/kg体重·分钟的剂量输注60分钟时，血管扩张剂、促尿钾排泄激素、长效利钠激素和心房利钠激素分别使CRH的循环浓度降低了84%、74%、67%和62%（每组P < 0.001）。血管扩张剂、促尿钾排泄激素、长效利钠激素和心房利钠激素分别使ACTH的循环浓度降低了58%、80%、81%和70%（P < 0.001），使皮质醇的循环浓度降低了73%、72%、73%和67%（P < 0.001）。在停止输注相应的心房利钠肽后，CRH、ACTH和皮质醇的降低持续1.5至3小时。这些数据，以及皮质醇上调心房利钠肽基因表达以及CRH和ACTH刺激心房利钠肽释放的知识，表明这四种心房利钠肽可能是一个复杂反馈系统的一部分，通过降低CRH的循环浓度来帮助调节皮质醇浓度，进而导致ACTH和皮质醇水平降低。
