[β-酪蛋白吗啡-7对白化大鼠幼崽产后发育行为影响的变化]

[Changes in beta-casomorphine-7 effect on behavior of albino rat pups in postnatal development].

作者信息

Dubynin V A, Ivleva Iu A, Malinovskaia I V, Kamenskiĭ A A, Andreeva L A, Alfeeva L Iu, Miasoedov N F

机构信息

Lomonosov State University, Institute of Molecular Genetics, Russian Academy of Sciences, Moscow.

出版信息

Zh Vyssh Nerv Deiat Im I P Pavlova. 2001 May-Jun;51(3):386-9.

PMID:11550650

Abstract

The analgetic effect of heptapeptide beta-casomorphine-7 in newborn albino rats (20 mg/kg, i.p.) was recorded already 14 days after birth in the "hot plate" test. The first signs of a possible influence of the peptide on motor activity were observed only at the age of 28 days. They are expressed in impairment of motor coordination and change in locomotion level ("Opto-Varimex" test). The obtained evidence probably reflect the processes of discrete maturation of different components of the opioid system of the rat brain.

摘要

在“热板”试验中，出生14天后就记录到了七肽β-酪蛋白吗啡-7（20毫克/千克，腹腔注射）对白化新生大鼠的镇痛作用。直到28日龄才观察到该肽对运动活动可能产生影响的最初迹象。这些迹象表现为运动协调性受损和运动水平改变（“Opto-Varimex”试验）。所获得的证据可能反映了大鼠脑阿片系统不同组分离散成熟的过程。