Hernandez R J, Strouse P J, Londy F J, Wakefield T W
Section of Pediatric Radiology, University of Michigan Health System, Ann Arbor, MI 48109-0252, USA.
Pediatr Radiol. 2001 Aug;31(8):589-93. doi: 10.1007/s002470100484.
To evaluate a gadolinium-enhanced MR angiography (Gd-MRA) imaging protocol for the assessment of thoracic vessels using double-dose gadolinium and quiet breathing. An animal model was used to simulate imaging in infants and young children.
Six baboons (Papio anubis), mean weight 5.7 kg, were sedated and intubated. After the injection of double-dose Gd-DTPA (0.2 mmol/kg) through a peripheral vein, a coronal spoiled 3D gradient-echo volume acquisition was obtained during quiet breathing. Two radiologists reviewed the images for visualization of aortic arch, brachiocephalic vessel origins, pulmonary arteries (central, upper lobe and descending branches), and pulmonary veins (upper and lower).
Visualization was excellent for the aortic arch, brachiocephalic vessel origins, and pulmonary arteries, including the hilar branches. Visualization was excellent for the lower and right upper pulmonary veins and fair for the left upper pulmonary vein. There was excellent agreement between radiologists.
Imaging of thoracic vessels with Gd-MRA using double gadolinium during quiet breathing was effective in our animal model. The advantages of this technique include a short imaging time and depiction of vascular segments--branches of pulmonary arteries and intraparenchymal segments of pulmonary veins--not optimally visualized with other non-invasive imaging techniques.
评估一种使用双倍剂量钆剂并在平静呼吸状态下进行钆增强磁共振血管造影（Gd-MRA）成像的方案，用于评估胸部血管。采用动物模型模拟婴幼儿成像。
对6只平均体重5.7千克的狒狒（埃及狒狒）进行镇静和插管。经外周静脉注射双倍剂量的钆喷酸葡胺（0.2毫摩尔/千克）后，在平静呼吸期间进行冠状面扰相3D梯度回波容积采集。两名放射科医生对图像进行评估，观察主动脉弓、头臂血管起始部、肺动脉（中央、上叶及降支）以及肺静脉（上、下）的显示情况。
主动脉弓、头臂血管起始部及肺动脉（包括肺门分支）显示极佳。下肺静脉及右上肺静脉显示极佳，左上肺静脉显示尚可。放射科医生之间的评估结果高度一致。
在我们的动物模型中，采用双倍钆剂并在平静呼吸状态下进行Gd-MRA胸部血管成像有效。该技术的优点包括成像时间短，以及能够显示其他非侵入性成像技术无法最佳显示的血管节段——肺动脉分支及肺静脉实质内节段。
