ElSohly M A, Feng S, Murphy T P, Warrington A W, Ross S, Nimrod A, Mehmedic Z, Fortner N
ElSohly Laboratories, Incorporated, Oxford, Mississippi 38655, USA.
J Anal Toxicol. 2001 Sep;25(6):476-80. doi: 10.1093/jat/25.6.476.
After incubation of delta9-tetrahydrocannabivarin with human hepatocytes, a major metabolic product was detected by gas chromatography-mass spectrometry that showed identical retention time and mass spectrum to the synthetic 11-nor-delta9-tetrahydrocannabivarin-9-carboxylic acid (11-nor-delta9-THCV-9-COOH). Analysis of human urine specimens from marijuana users and plasma samples from Marinol users showed that 11-nor-delta9-THCV-9-COOH was only present in urine specimens of marijuana users. These results supported the conclusion that identification of 11-nor-delta9-THCV-9-COOH in a donor's urine specimen indicates the use or ingestion of cannabis-related product(s) and would not explain the sole use of Marinol.
将Δ⁹-四氢大麻二酚与人类肝细胞一起孵育后，通过气相色谱-质谱法检测到一种主要代谢产物，其保留时间和质谱与合成的11-去甲-Δ⁹-四氢大麻二酚-9-羧酸（11-去甲-Δ⁹-THCV-9-COOH）相同。对大麻使用者的人类尿液样本和服用屈大麻酚者的血浆样本进行分析后发现，11-去甲-Δ⁹-THCV-9-COOH仅存在于大麻使用者的尿液样本中。这些结果支持了以下结论：在供体尿液样本中鉴定出11-去甲-Δ⁹-THCV-9-COOH表明使用或摄入了与大麻相关的产品，而无法解释仅使用屈大麻酚的情况。
