Järhult J, Hillman J, Mellander S
Acta Physiol Scand. 1975 Jan;93(1):129-34. doi: 10.1111/j.1748-1716.1975.tb05798.x.
The effects of moderate arterial hyperosmolality (+20 mOsm/kg H2O), produced by short term intravenous hypertonic infusion, on vascular resistance in skin, skeletal muscle, intestine, and kidney were analyzed in the anesthetized cat. Vascular resistance decreased in all four regions in response to the hypertonicity both before and after regional sympathectomy and the effects were not significantly altered by beta-adreno-ceptor blockade. Arterial blood pressure rose during the hypertonic infusion despite the decreased vascular resistance and an unchanged heart rate, indicating an increased stroke volume and cardiac output. Similar increases of arterial osmolality are known to occur in heavy exercise and in hemorrhage. The present results may therefore suggest that blood borne hyperosmolality is a factor which can contribute to the overall cardiovascular adjustments in these situations.
通过短期静脉输注高渗溶液产生的中度动脉高渗（+20 mOsm/kg H₂O）对麻醉猫皮肤、骨骼肌、肠道和肾脏血管阻力的影响进行了分析。在区域交感神经切除术前和术后，高渗状态均使所有四个区域的血管阻力降低，且β肾上腺素能受体阻断并未显著改变这些作用。尽管血管阻力降低且心率不变，但高渗输注期间动脉血压仍升高，表明心输出量和每搏输出量增加。已知剧烈运动和出血时也会出现类似的动脉渗透压升高。因此，目前的结果可能表明，血源性高渗是这些情况下有助于整体心血管调节的一个因素。
