Couet J, Belanger M M, Roussel E, Drolet M C
Institut universitaire de cardiologie et de pneumologie de l'Université Laval, Centre de recherche Hôpital Laval, 2725 Chemin Sainte-Foy, Sainte-Foy, Quebec G1V 4G5 Canada.
Adv Drug Deliv Rev. 2001 Jul 28;49(3):223-35. doi: 10.1016/s0169-409x(01)00139-9.
Originally described in the 1950s caveolae are morphologically identifiable as small omega-shaped plasma membrane invaginations present in most cell types. Caveolae are particularly abundant in adipocytes, fibroblasts, type 1 pneumocytes, endothelial and epithelial cells as well as in smooth and striated muscle cells. The first proposed function for caveolae was that of mediating the internalisation and transendothelial trafficking of solutes. Caveolae have been the object of intense research since the discovery of a biochemical marker protein, caveolin, in the early 1990s. Three genes encoding for caveolins have been characterised in mammals. Caveolins (18-24 kDa) are integral membrane proteins that constitute the major protein component of caveolar membrane in vivo. In addition to a structural role of caveolins in the formation of caveolae, caveolin protein interacts directly, and in a regulated manner, with a number of signalling molecules. We present here a general overview of the current knowledge on the structural role of caveolin in caveolae formation, and implication of caveolin in the control of cell signalling.
小窝最初于20世纪50年代被描述，在形态学上可识别为存在于大多数细胞类型中的小的Ω形质膜内陷。小窝在脂肪细胞、成纤维细胞、Ⅰ型肺细胞、内皮细胞和上皮细胞以及平滑肌和横纹肌细胞中尤其丰富。小窝最初被提出的功能是介导溶质的内化和跨内皮运输。自20世纪90年代初发现一种生化标记蛋白小窝蛋白以来，小窝一直是深入研究的对象。在哺乳动物中已鉴定出三个编码小窝蛋白的基因。小窝蛋白（18 - 24 kDa）是整合膜蛋白，在体内构成小窝膜的主要蛋白质成分。除了小窝蛋白在小窝形成中的结构作用外，小窝蛋白还以一种受调控的方式直接与许多信号分子相互作用。我们在此概述目前关于小窝蛋白在小窝形成中的结构作用以及小窝蛋白在细胞信号控制中的作用的相关知识。
Zotero 插件