Sheth Vinit, Wang Lin, Bhattacharya Resham, Mukherjee Priyabrata, Wilhelm Stefan
Stephenson School of Biomedical Engineering, University of Oklahoma, 173 Felgar St, Norman, OK 73019, USA.
Department of Obstetrics and Gynecology, Peggy and Charles Stephenson Cancer Center, University of Oklahoma Health Science Center, 800 NE 10th St, Oklahoma City, OK 73104, USA.
Adv Funct Mater. 2021 Feb 17;31(8). doi: 10.1002/adfm.202007363. Epub 2020 Nov 12.
Nanoparticle transport across tumor blood vessels is a key step in nanoparticle delivery to solid tumors. However, the specific pathways and mechanisms of this nanoparticle delivery process are not fully understood. Here, the biological and physical characteristics of the tumor vasculature and the tumor microenvironment are explored and how these features affect nanoparticle transport across tumor blood vessels is discussed. The biological and physical methods to deliver nanoparticles into tumors are reviewed and paracellular and transcellular nanoparticle transport pathways are explored. Understanding the underlying pathways and mechanisms of nanoparticle tumor delivery will inform the engineering of safer and more effective nanomedicines for clinical translation.
纳米颗粒穿过肿瘤血管是纳米颗粒递送至实体瘤的关键步骤。然而，这一纳米颗粒递送过程的具体途径和机制尚未完全明确。本文探讨了肿瘤脉管系统和肿瘤微环境的生物学和物理特性，并讨论了这些特性如何影响纳米颗粒穿过肿瘤血管的运输。综述了将纳米颗粒递送至肿瘤的生物学和物理方法，并探究了纳米颗粒的细胞旁和跨细胞运输途径。了解纳米颗粒肿瘤递送的潜在途径和机制，将为临床转化中更安全、更有效的纳米药物工程提供依据。
