FOXC2是一种翼状螺旋基因，可对抗肥胖、高甘油三酯血症和饮食诱导的胰岛素抵抗。

FOXC2 is a winged helix gene that counteracts obesity, hypertriglyceridemia, and diet-induced insulin resistance.

作者信息

Cederberg A, Grønning L M, Ahrén B, Taskén K, Carlsson P, Enerbäck S

机构信息

Medical Genetics, Department of Medical Biochemistry, Göteborg University, Box 440, SE-405 30, Göteborg, Sweden.

出版信息

Cell. 2001 Sep 7;106(5):563-73. doi: 10.1016/s0092-8674(01)00474-3.

DOI:10.1016/s0092-8674(01)00474-3

PMID:11551504

Abstract

Obesity, hyperlipidemia, and insulin resistance are common forerunners of type 2 diabetes mellitus. We have identified the human winged helix/forkhead transcription factor gene FOXC2 as a key regulator of adipocyte metabolism. Increased FOXC2 expression, in adipocytes, has a pleiotropic effect on gene expression, which leads to a lean and insulin sensitive phenotype. FOXC2 affects adipocyte metabolism by increasing the sensitivity of the beta-adrenergic-cAMP-protein kinase A (PKA) signaling pathway through alteration of adipocyte PKA holoenzyme composition. Increased FOXC2 levels, induced by high fat diet, seem to counteract most of the symptoms associated with obesity, including hypertriglyceridemia and diet-induced insulin resistance--a likely consequence hereof would be protection against type 2 diabetes.

摘要

肥胖、高脂血症和胰岛素抵抗是2型糖尿病常见的先兆。我们已确定人类翼状螺旋/叉头转录因子基因FOXC2是脂肪细胞代谢的关键调节因子。脂肪细胞中FOXC2表达增加对基因表达具有多效性作用，可导致瘦型且胰岛素敏感的表型。FOXC2通过改变脂肪细胞PKA全酶组成来提高β-肾上腺素能-cAMP-蛋白激酶A（PKA）信号通路的敏感性，从而影响脂肪细胞代谢。高脂饮食诱导的FOXC2水平升高似乎可抵消与肥胖相关的大多数症状，包括高甘油三酯血症和饮食诱导的胰岛素抵抗，由此可能带来预防2型糖尿病的效果。