Retamal P
Departamento de Psiquiatría, Campus Oriente, Facultad de Medicina, Universidad de Chile.
Rev Med Chil. 2001 Jul;129(7):813-8.
Considering the prevalence of major unipolar depression, the economical costs of its management and the different medications available for its treatment, it is imperative to have a good knowledge of the basic principles used to classify anti depressive medications. A good acquaintance on their mechanisms of action on neurotransmission and receptors, wil allow a better understanding of their therapeutic action and secondary effects. Tricyclics, non selective MAO inhibitors, reversible MAO inhibitors, selective serotonin reuptake inhibitors, dopamine and noradrenalin reuptake inhibitors, 5-HT2 blockers with serotonin reuptake blocking effect, serotonin, noradrenalin and dopamine reuptake inhibitors, alfa 2 receptor blockers and 5-HT/2-3 inhibitors are the eight available types of antidepressants.
鉴于重度单相抑郁症的患病率、其治疗的经济成本以及可用于治疗的不同药物，有必要深入了解用于抗抑郁药物分类的基本原则。熟悉它们对神经传递和受体的作用机制，将有助于更好地理解其治疗作用和副作用。三环类药物、非选择性单胺氧化酶抑制剂、可逆性单胺氧化酶抑制剂、选择性5-羟色胺再摄取抑制剂、多巴胺和去甲肾上腺素再摄取抑制剂、具有5-羟色胺再摄取阻断作用的5-HT2阻断剂、5-羟色胺、去甲肾上腺素和多巴胺再摄取抑制剂、α2受体阻断剂以及5-HT/2-3抑制剂是现有的八种抗抑郁药类型。
