Bernstein J J, Wells M R, Bernstein M E
Adv Neurol. 1975;12:439-51.
Within 60 to 90 days of spinal cord hemisection or hemisection, Gelfoam, water implantation in the lesion site, ventral horn neurons 0 to 5 mm proximal to the site of lesion form varicosities along the dendrite. The varicosities form on peripheral dendrites at 10 days and progressively involve the entire dendritic shaft by 60 to 90 days. Following spinal cord hemisection and Gelfoam puromycin implantation the neurons in the ventral horn are resistant to varicosity formation. Sixty days after hemisection puromycin-treated neurons form a few varicosities on occasional peripheral dendrites with no further involvement of the dendrite by 90 days postlesion. The neuroglial reaction to hemisection is not altered by puromycin treatment. The correlation of inhibition of protein synthesis and resistance to dendritic varicosity formation is discussed.
在脊髓半切或半横断术后60至90天内，在损伤部位植入明胶海绵、水，损伤部位近端0至5毫米的腹角神经元在树突上形成静脉曲张。静脉曲张在10天时在外周树突上形成，并在60至90天时逐渐累及整个树突轴。脊髓半切和明胶海绵嘌呤霉素植入后，腹角神经元对静脉曲张形成具有抗性。半切术后60天，经嘌呤霉素处理的神经元在偶尔的外周树突上形成一些静脉曲张，损伤后90天时树突不再进一步受累。嘌呤霉素处理不会改变对半切的神经胶质反应。讨论了蛋白质合成抑制与对树突静脉曲张形成抗性之间的相关性。
