Garfias Y, Rojas Ramos E, Ledesma R, Chávez R, Hernández J, Zenteno E
Departamento de Bioquímica, Instituto Nacional de Enfermedades Respiratorias, Laboratorio de Inmunología, Departamento de Bioquímica, Facultad de Medicina, UNAM, México, DF.
Rev Alerg Mex. 2001 May-Jun;48(3):68-74.
The atopic diseases are mediated by type I hypersensitivity. These disorders are multifactorial, although, the inherency is probably the most important cause. The disregulation of the Th1/Th2 immune response is one of the predominant factors on the generation and maintenance on the atopic process. We analyze the mechanisms of the regulation of the response Th1/Th2, the recent theories of the disregulation on this response as an etiology, the soluble factors as cytokines, chemokines and their receptors, surface cell markers and transcriptional factors recently mentioned to be important on this disregulation mechanism. Otherwise, we propose some general considerations and perspectives.
特应性疾病由I型超敏反应介导。这些疾病是多因素的，不过，遗传因素可能是最重要的原因。Th1/Th2免疫反应失调是特应性进程发生和维持的主要因素之一。我们分析了Th1/Th2反应的调节机制、关于这种反应失调作为病因的最新理论、作为细胞因子、趋化因子及其受体的可溶性因子、表面细胞标志物以及最近提到的在这种失调机制中起重要作用的转录因子。此外，我们提出了一些一般性的考虑和观点。
