Keeler R
Am J Physiol. 1975 Jun;228(6):1725-8. doi: 10.1152/ajplegacy.1975.228.6.1725.
Rats with bilateral lesions in the preoptic area showed a normal pattern of urineand electrolyte excretion under resting conditions but complete absence of a natriuretic response to unilateral carotid baroreceptor stimulation and also a significant reduction in the rate of sodium excretion after saline loading and after a high-sodium intake. Measurements of renal clearance did not show any significant differences in glomerular filtration rate, renal plasma flow, or filtration fraction between normal and preoptic-lesion rats. Apart from the test situations used above, rats with preoptic lesions were apparently able to regulate their sodium metabolism normally because after 3 wk on a high-sodium intake their plasma and extracellular fluid volumes, plasma electrolytes, osmolaity, and mean arterial pressures were indistinguishable from normal rats. It is suggested that the preoptic component of the baroreceptor reflex pathway mighthave an input into a hypothalamic area controlling sodium excretion.
视前区双侧受损的大鼠在静息状态下尿液和电解质排泄模式正常，但对单侧颈动脉压力感受器刺激完全没有利钠反应，并且在生理盐水负荷后和高钠摄入后钠排泄率也显著降低。肾清除率测量结果显示，正常大鼠和视前区受损大鼠之间的肾小球滤过率、肾血浆流量或滤过分数没有任何显著差异。除了上述测试情况外，视前区受损的大鼠显然能够正常调节其钠代谢，因为在高钠摄入3周后，它们的血浆和细胞外液体积、血浆电解质、渗透压和平均动脉压与正常大鼠没有区别。有人认为，压力感受器反射通路的视前区成分可能会向控制钠排泄的下丘脑区域输入信号。
