Suzuki Y, Ueda H, Toribe Y
Division of Pediatric Neurology, Osaka Medical Center and Research Institute for Maternal and Child Health, Izumi, Osaka.
No To Hattatsu. 2001 Sep;33(5):422-5.
Proton magnetic resonance spectroscopy (MRS) can noninvasively detect brain metabolites in vivo. A girl with the neonatal type of nonketotic hyperglycinemia was studied by MRS using a long-echo-time point-resolved technique. The proton spectrum from a volume of 15 x 15 x 15 mm cube located in her left parietal white matter exhibited a glycine signal at 3.5 ppm. Subsequent measurements (3 months to 2 years of age) showed a time course of glycine/creatine ratio similar to the changes of the glycine levels in the blood and cerebrospinal fluid. Our findings suggest that MRS is a noninvasive diagnostic tool useful in monitoring the brain glycine level directly in patients with nonketotic hyperglycinemia.
质子磁共振波谱（MRS）能够在体内非侵入性地检测脑代谢物。采用长回波时间点分辨技术，通过MRS对一名患有新生儿型非酮症高甘氨酸血症的女孩进行了研究。在她左侧顶叶白质中一个15×15×15立方毫米的体积区域所获得的质子谱显示，在3.5 ppm处有甘氨酸信号。随后的测量（3个月至2岁）显示，甘氨酸/肌酸比值的时间变化过程与血液和脑脊液中甘氨酸水平的变化相似。我们的研究结果表明，MRS是一种非侵入性诊断工具，可用于直接监测非酮症高甘氨酸血症患者的脑甘氨酸水平。
