[中毒性肝炎时病变肝脏代谢适应的分子机制]
[Molecular mechanisms of metabolic adaptation in pathological changed liver during toxic hepatitis ].
作者信息
Zimin Iu V, Siatkin S P, Berezov T T
机构信息
Molecular Pathology Group, Research Institute of Traumatology and Orthopedics, Verkhne-Volzhskaya nab. 18, Nizhniy Novgorod 603155, Russia.
出版信息
Vopr Med Khim. 2001 May-Jun;47(3):346-52.
Possible molecular mechanisms underlying changes in catalytical properties of alcohol dehydrogenase (ADH) and lactate dehydrogenase (LDH) were studied at toxic hepatitis. The development of toxic hepatitis is accompanied by significant changes in the activity of ADH and LDH assayed in subcellular fractions and kinetic characteristics of these enzymes. This can result in an increase cellular level of acetylaldehyde and lactate which promotes the development of liver cirrhosis.
研究了中毒性肝炎时乙醇脱氢酶（ADH）和乳酸脱氢酶（LDH）催化特性变化的潜在分子机制。中毒性肝炎的发展伴随着亚细胞组分中检测到的ADH和LDH活性以及这些酶动力学特性的显著变化。这可能导致细胞内乙醛和乳酸水平升高，从而促进肝硬化的发展。
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