氯化钾中铝离子与钙离子之间的相互作用使胃肠平滑肌去极化。

Interaction between aluminum and calcium ions in potassium chloride depolarized gastrointestinal smooth muscle.

作者信息

Hava M, Hurwitz A

出版信息

Arch Int Pharmacodyn Ther. 1975 Apr;214(2):213-23.

Abstract

Aluminum chloride (5 times 10-minus 4 M) abolished the inhibitory effects of papaverine chloride (1.5 times 10- minus 5 M) on contractions of guinea-pig ileum and rat colon evoked by calcium in Tyrode's solution containing high KC1. The inhibitory effects of cocaine hydrochloride (10- minus 3 M) and MgSO4 (2 times 10- minus 2 M) were not antagonized. In isolated rat colon depolarized by partial exchange of NaCl by 40 mM KC1, AlC13 decreased the phasic contractions, slowed the onset of tonic contraction while increasing maximal tone and induced superimposed spontaneous activity during the tonic phase. Similar changes were evoked by increasing the CaCl2 concentration from 1.8 times 10- minus 3 M to 7.2 times 10- minus 3 M. The increase in spontaneous activity was not blocked by atropine sulfate (10- minus 7 minus 10- minus 4 M) but was partially antagonized by 10- minus 3 M caffeine and completely blocked by papaverine chloride (5 times 10- minus 4 M). More than one aluminum site of action is proposed for effects of aluminum on the gastro-intestinal smooth muscle.

摘要

氯化铝（5×10⁻⁴ M）消除了氯化罂粟碱（1.5×10⁻⁵ M）对含高KCl的台氏液中钙诱发的豚鼠回肠和大鼠结肠收缩的抑制作用。盐酸可卡因（10⁻³ M）和MgSO₄（2×10⁻² M）的抑制作用未被拮抗。在通过用40 mM KCl部分置换NaCl而 depolarized 的离体大鼠结肠中，AlC1₃降低了相性收缩，延缓了紧张性收缩的起始，同时增加了最大张力，并在紧张期诱导了叠加的自发活动。将CaCl₂浓度从1.8×10⁻³ M增加到7.2×10⁻³ M也引起了类似的变化。自发活动的增加未被硫酸阿托品（10⁻⁷ - 10⁻⁴ M）阻断，但被10⁻³ M咖啡因部分拮抗，并被氯化罂粟碱（5×10⁻⁴ M）完全阻断。对于铝对胃肠平滑肌的作用，提出了不止一个铝作用位点。（注：原文中“depolarized”这个词在这个语境下不太符合正常逻辑，推测可能是“去极化”的错误表述，这里先按原文翻译）