Swingle K F, Scherrer R A, Grant T J
Arch Int Pharmacodyn Ther. 1975 Apr;214(2):240-9.
The antiinflammatory activity of R-803 (alpha-methyl-3-phenyl-7-benzofuranacetic acid), a new nonsteroidal drug, has been demonstrated. The oral administration of R-803 inhibits carrageenan-induced edema of the rat's paw, ultraviolet-induced erythema of guinea-pig skin, adjuvant-induced and 6-sulfonamidoindazole-induced arthritides of the rat at doses in the range of 1.0 to 6.0 mg/kg. It also inhibits the cotton pellet-induced granuloma in the rat at higher doses.
已证实一种新型非甾体药物R - 803（α-甲基-3-苯基-7-苯并呋喃乙酸）具有抗炎活性。口服R - 803能抑制角叉菜胶诱导的大鼠足爪水肿、紫外线诱导的豚鼠皮肤红斑、佐剂诱导和6-磺酰胺基吲唑诱导的大鼠关节炎，剂量范围为1.0至6.0毫克/千克。在较高剂量时，它还能抑制大鼠棉球诱导的肉芽肿。
