Wellens D, Snoeckx L, De Reese R, Kruger R, Van de Water A, Woutens L, Reneman R S
Arch Int Pharmacodyn Ther. 1975 May;215(1):119-32.
Erythro-1-(1-[2-(1,4-benzodioxan-2-yl)-2-OH-ET]-4-piperidyl)-2-benzimidazolinone (R 28935), provokes marked antihypertensive effects lasting several hours in conscious SHR (0.63 to 40 mg/kg i.p.) and beagles with renal hypertension (1.25 mg/kg p.o.). In SHR, this compound induces much less bradycardia, compared to equiactive hypotensive doses of clonidine, guanethidine and propranolol. Significant postural hypotension during tilting, is induced by guanethidine and mecamylamine but not by R 28935. In anaesthetized beagles with renal hypertension, the lowering of the blood pressure by R 28935, (0.02-0.64 mg/kg i.v.) is associated with a considerable decrease in the total peripheral vascular resistance, whereas the myocardial function is not affected. R 28935 is considered a potent antihypertensive drug, with attractive haemodynamic characteristics.
1-（1-[2-（1,4-苯并二恶烷-2-基）-2-羟基乙基]-4-哌啶基）-2-苯并咪唑啉酮（R 28935），在清醒的自发性高血压大鼠（腹腔注射0.63至40毫克/千克）和肾性高血压比格犬（口服1.25毫克/千克）中可引发显著的降压作用，持续数小时。在自发性高血压大鼠中，与等效降压剂量的可乐定、胍乙啶和普萘洛尔相比，该化合物引起的心动过缓要少得多。胍乙啶和美加明可引起倾斜过程中的显著体位性低血压，但R 28935不会。在麻醉的肾性高血压比格犬中，R 28935（静脉注射0.02 - 0.64毫克/千克）降低血压与总外周血管阻力的显著降低有关，而心肌功能不受影响。R 28935被认为是一种有效的降压药物，具有吸引人的血流动力学特性。
