Dafny N
Arch Int Pharmacodyn Ther. 1975 May;215(1):31-9.
Paired click stimuli applied at varying time intervals were used to study the responses to polysynaptic input in the globus pallidus of freely behaving rats chronically implanted with semi-microelectrodes (60 mu). The average acoustic evoked responses (AAER) to 32 successive acoustic stimuli consisted of large amplitude potentials of long duration composed of 5 components (P1, N1, P2, N2 and P3) with latencies. The neuronal recovery function was long. Intraperitoneal reserpine administration heightened the amplitude of the AAER and shortened the neuronal recovery function. L-DOPA injection 2 hr after resperine treatment caused further heightening of the AAER but had no effect on the neuronal recovery function. When L-DOPA was given first, the AAER increased in the amplitude response and the neuronal recovery function was shortened consistently. Reserpine treatment 2 hr after L-DOPA, decreased the amplitude of the AAER but had not marked effect on the neuronal recovery function.
对长期植入半微电极（60微米）的自由活动大鼠，施加不同时间间隔的成对点击刺激，以研究苍白球对多突触输入的反应。对32个连续声刺激的平均听觉诱发电位（AAER）由持续时间长的大幅度电位组成，该电位由5个成分（P1、N1、P2、N2和P3）组成，具有潜伏期。神经元恢复功能较长。腹腔注射利血平可提高AAER的幅度并缩短神经元恢复功能。利血平治疗后2小时注射左旋多巴可使AAER进一步升高，但对神经元恢复功能无影响。当先给予左旋多巴时，AAER的幅度反应增加，神经元恢复功能持续缩短。左旋多巴后2小时给予利血平治疗，可降低AAER的幅度，但对神经元恢复功能无明显影响。
