血清肌酸激酶BB与免疫球蛋白G相关。
Serum creatine kinase BB linked to immunoglobulin G.
作者信息
Bohner J, Stein W, Kuhlmann E, Eggstein M
出版信息
Clin Chim Acta. 1979 Sep 15;97(1):83-8. doi: 10.1016/0009-8981(79)90027-5.
We describe an atypical form of creatine kinase in the serum of a woman after myocardial infarction. Electrophoresis on agarose gel showed a single fraction between CK-MM and CK-MB isoenzymes. After ion-exchange chromatography on DEAE-Sephadex A-50 we isolated the atypical CK and CK-BB as detected by electrophoresis of the eluted fractions. Results of our immunological investigations and exclusion chromatography clearly demonstrate that the atypical CK consists of complexes with high molecular masses formed by CK-BB isoenzyme and immunoglobulin G. The clinical significance, if any, of this Macro CK has yet to be determined.
我们描述了一名女性心肌梗死后血清中一种非典型形式的肌酸激酶。琼脂糖凝胶电泳显示在CK-MM和CK-MB同工酶之间有单一成分。在DEAE-葡聚糖A-50上进行离子交换色谱后，我们分离出了非典型CK，并通过洗脱组分的电泳检测到了CK-BB。我们的免疫学研究和排阻色谱结果清楚地表明，非典型CK由CK-BB同工酶和免疫球蛋白G形成的高分子量复合物组成。这种大分子CK的临床意义（如果有）尚未确定。
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