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新型三磷酸类似物:核糖核苷和脱氧核糖核苷(α-P-硼代、α-P-硫代)三磷酸的合成与性质

Synthesis and properties of novel triphosphate analogues: ribonucleoside and deoxyribonucleoside (alpha-P-borano, alpha-P-thio)triphosphates.

作者信息

Lin J, Porter K W, Shaw B R

机构信息

Paul M. Gross Chemical Laboratory, Department of Chemistry, Duke University, Durham, North Carolina 27708-0346, USA.

出版信息

Nucleosides Nucleotides Nucleic Acids. 2001 Apr-Jul;20(4-7):1019-23. doi: 10.1081/NCN-100002482.

Abstract

The first ribo- and deoxyribo-nucleoside (alpha-P-borano, alpha-P-thio)triphosphates have been synthesized. The chemical and biochemical properties of adenosine (alpha-P-borano, alpha-P-thio)triphosphate and thymidine (alpha-P-borano, alpha-P-thio) triphosphate have been investigated.

摘要

已合成了首批核糖核苷和脱氧核糖核苷(α-P-硼烷、α-P-硫代)三磷酸酯。对腺苷(α-P-硼烷、α-P-硫代)三磷酸酯和胸苷(α-P-硼烷、α-P-硫代)三磷酸酯的化学和生化性质进行了研究。

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