Engineering preferences of hairpin PNA binding to complementary DNA: effect of N7G in aeg/aep PNA backbone.
作者信息
Kumar V A, D'Costa M, Ganesh K N
机构信息
Division of Organic Chemistry (Synthesis), National Chemical Laboratory, Pune, Maharashtra, India.
出版信息
Nucleosides Nucleotides Nucleic Acids. 2001 Apr-Jul;20(4-7):1187-91. doi: 10.1081/NCN-100002516.
PMID:11562983
Abstract
AegPNA and aepPNA monomeric units bearing the N7-guanine nucleobase as a substitute for C+ have been demonstrated to bind to a GC base-pair of a duplex in a pH-independent manner when placed in the third strand. The aepPNA backbone exerts a preference for binding in the antiparallel Hoogsteen mode over the parallel Hoogsteen mode.
摘要
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