旨在了解三磷酸卡波韦对野生型和突变型HIV-1逆转录酶抑制作用的机制研究。
Mechanistic studies to understand the inhibition of wild type and mutant HIV-1 reverse transcriptase by Carbovir-triphosphate.
作者信息
Ray A S, Anderson K S
机构信息
Department of Pharmacology, Yale University School of Medicine, 333 Cedar Street, New Haven, Connecticut 06520-8066, USA.
出版信息
Nucleosides Nucleotides Nucleic Acids. 2001 Apr-Jul;20(4-7):1247-50. doi: 10.1081/NCN-100002528.
Abacavir (1592U89) has recently been approved by the FDA for treatment of HIV infection. Transient kinetic studies were carried out to better understand the interaction of the active metabolite of Abacavir (Carbovir-triphosphate) with wild type and mutant HIV-1 reverse transcriptase. Some of the data is summarized and used as a basis for discussion of inhibition by CBVTP and previously studied nucleoside analogs.
阿巴卡韦（1592U89）最近已获美国食品药品监督管理局（FDA）批准用于治疗HIV感染。进行了瞬态动力学研究，以更好地了解阿巴卡韦的活性代谢物（卡波韦三磷酸）与野生型和突变型HIV-1逆转录酶之间的相互作用。部分数据进行了总结，并用作讨论CBVTP和先前研究的核苷类似物抑制作用的基础。
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