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Structure-activity relationships of apio nucleosides as potential antiviral agents.

作者信息

Jeong L S, Moon H R, Hong J H, Yoo S J, Choi W J, Kim H O, Ahn H S, Baek H W, Chun M W, Kim H D, Kim J, Choi J R

机构信息

College of Pharmacy, Ewha Womans University, Seoul, Korea.

出版信息

Nucleosides Nucleotides Nucleic Acids. 2001 Apr-Jul;20(4-7):657-60. doi: 10.1081/NCN-100002344.

DOI:10.1081/NCN-100002344
PMID:11563085
Abstract

Several types of novel apio nucleosides were synthesized starting from 1,3-dihydroxyacetone and evaluated for antiviral activity. Among compounds tested, amino substituted apio dideoxynucleosides exhibited anti-HBV activity, while thioapio dideoxynucleosides were found to be active against HIV-1. Apio dideoxydidehydro nucleosides showed moderate to potent anti-HCMV activity, but their bioisosteric thioapio dideoxydidehydro nucleosides did not exhibit any significant antiviral activity.

摘要

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