Milesi V, Rebolledo A, Gómez Alvis A, Sanz N, Tommasi J, Drago A, Raingo J, Rinaldi G J, Grassi de Gende A O
Departamento de Ciencias Biológicas, Facultad de Ciencias Exactas, UNLP, Servicio de Cirugía Cardiovascular, Hospital San Juan de Dios, La Plata, Provincia de Buenos Aires.
Medicina (B Aires). 2001;61(4):481-90.
The human saphenous vein (HSV) is currently used as a graft in coronary revascularization as well as in some other vascular beds, namely those of the inferior limbs. Since a significant proportion of HSV grafts develop stenosis, many studies have focused on the factors that could promote graft failure. This article reviews the results on structural and functional features that might be concurrent in the production of saphenous vein graft stenosis. The reactivity of HSV to several physiological agonists is analyzed, including those derived from the endothelium with contractile or relaxing properties, since these are relevant inducers of graft spasm and/or modifiers of the expression of graft factors involved in either tissue growth or thrombotic-atherosclerotic processes. Mechanisms that regulate vascular smooth muscle contractile state, in particular the activity of K+ channels of the plasma membrane, are described.
人隐静脉（HSV）目前被用作冠状动脉血运重建以及其他一些血管床（即下肢血管床）的移植物。由于相当一部分HSV移植物会发生狭窄，许多研究都集中在可能导致移植物失败的因素上。本文综述了可能与隐静脉移植物狭窄形成同时出现的结构和功能特征的研究结果。分析了HSV对几种生理激动剂的反应性，包括那些具有收缩或舒张特性的内皮衍生激动剂，因为这些是移植物痉挛的相关诱导剂和/或参与组织生长或血栓 - 动脉粥样硬化过程的移植物因子表达的调节剂。描述了调节血管平滑肌收缩状态的机制，特别是质膜钾通道的活性。
